A man reflects with quiet satisfaction as he reviews positive echo results, surrounded by reminders of gratitude, strength, and progress in a warm, sunlit room.
I wanted to share a long-overdue health update about what has happened this year and why I can finally talk about it. I recently had my second Camzyos cardiology echo and doctor’s visit of the year. I normally go every six months, and this visit gave me my best numbers yet.
On Camzyos, my obstruction is much better controlled. My echo looked fantastic, so I included a table below comparing my results before and after starting Camzyos.
When I first started Camzyos, I was not getting my refills consistently because of REMS requirements and the timing of my echoes and doctor’s visits. This created gaps in treatment. Once my refills became consistent and those delays stopped, the treatment began working much better.
| Time point | Camzyos status | Ejection fraction | LVOT gradient at rest | LVOT gradient with Valsalva / provocation | Mitral valve / SAM notes | What changed |
|---|---|---|---|---|---|---|
| Apr. 2021 | Before Camzyos | 65-70% | 90 mmHg | 94 mmHg | Systolic anterior motion (SAM); mild-to-moderate mitral regurgitation | Historical severe obstruction |
| Aug. 2024 | Before Camzyos | 60-65% | 27 mmHg | 51 mmHg | SAM; moderate mitral regurgitation | Still obstructive, though less severe than 2021 |
| May 2025 | Before starting Camzyos protocol | 50-55% | 65 mmHg | 100 mmHg | SAM; mild mitral regurgitation | Strong pre-treatment baseline: significant obstruction |
| Jul. 2025 | Early Camzyos follow-up | 60-65% | Not listed in summary | 57 mmHg | Trace mitral regurgitation | Early improvement from the May 2025 provoked gradient |
| Aug.-Nov. 2025 | On Camzyos, still being adjusted/monitored | 60-65% where listed | Varied; one report listed 39 mmHg | Varied, including 84-145 mmHg in follow-up echoes | Mitral regurgitation generally mild or not significant in these reports | Improvement was not a perfectly straight line |
| Jan. 2026 | On Camzyos | 60-65% | 10 mmHg | 24 mmHg | No major valve issue highlighted in the summary | Obstruction was much lower than the May 2025 baseline |
| Jun. 2026 | On Camzyos, latest echo | 55-60% | 3 mmHg | 8 mmHg | Mild SAM noted, but “no outflow obstruction”; mild mitral regurgitation | Best documented result in this set: very low gradients |
So yes, I am in a much better place. My heart is working with far less obstruction than it has in years. Between Camzyos and taking Metoprolol ER 200 mg twice daily, I am cautiously optimistic that I can remain on this path.
These results do not mean that my hypertrophic cardiomyopathy is gone, but they do show that the treatment is doing what it is supposed to do. After years of seeing much higher numbers, I am grateful to finally be able to share some genuinely encouraging news.
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